赵金存
发布时间:2016-10-12  (浏览:)
 
赵金存教授2002年本科毕业于北京大学医学部基础医学系;2007获北京大学医学部免疫学系免疫学博士;20078月至20128月于美国爱荷华大学(University of Iowa)微生物系开展博士后研究;20129月任美国爱荷华大学微生物系助理研究科学家。2015年赵金存博士入选国家第十一批“千人计划”青年项目,并于20158月全职加入广州医科大学/广州呼吸疾病研究所/呼吸疾病国家重点实验室工作,现任教授、博士生导师、Journal of Virology杂志编委

赵金存教授主要关注多种呼吸道冠状病毒和流感病毒等所致重症肺炎,以及其它新发突发病毒性传染病。近年来在ImmunityJ Clin InvestPNASPLoS PathogJ Virol等杂志发表原创性研究论文30多篇。研究内容主要包括但不局限于:

1.  感染动物模型的构建:应用重组腺病毒载体、基因修饰等技术,构建高效动物模型,模拟呼吸道病毒和其它新发突发病毒感染,为后续的研究提供支持。

2.  免疫致病机制的研究:重点研究多种免疫细胞和分子(包括T细胞、B细胞、巨噬细胞、树突细胞、干扰素和趋化因子等)在病毒感染致病机制中的作用,为抗病毒感染药物和疫苗开发提供理论基础。

3.  开发高效的治疗性药物、抗体和预防性疫苗,广泛应用于应急救治病人和防控疫情播散。

我们关注本领域国际研究热点,应用前沿研究方法,以其解决公共卫生安全重大关切问题。欢迎有志青年加入我们的团队,投身于新发突发传染病研究!

邮箱:zhaojincun@gird.cn

 

 

代表性学术论文(#First authors, *Corresponding authors

1.      Zhao J#, *, Zhao J#, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S*. Airway Memory CD4 T Cells Orchestrate Protective Immunity against Emerging Human Respiratory Coronaviruses. Immunity. 2016 Jun 21;44(6):1379-91.

2.      Zhao J#, *, Vijay R, Zhao J, Gale M Jr, Diamond MS, Perlman S*. MAVS expressed by hematopoietic cells is critical for control of West Nile virus infection and pathogenesis. J Virol. 2016 Jul 27;90(16):7098-108.

3.      Corti D#, Zhao J#, Pedotti M, Simonelli L, Agnihothram S, Fett C, Fernandez-Rodriguez B, Foglierini M, Agatic G, Vanzetta F, Gopal R, Langrish CJ, Barrett N.A, Sallusto F, Baric RS, Varani L, Zambon M, Perlman S, Lanzavecchia A*. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci U S A. 2015 Aug; 112:10473-8. (Commentary by Dennis R. Burtona and Erica Ollmann Saphire)

4.      Zhao J#, Perera RA, Kayali G, Meyerholz D, Perlman S*, Peiris M*. Passive immunotherapy with dromedary immune serum in an experimental animal model for MERS coronavirus infection. J Virol. 2015 Jun; 89:6117-20.

5.      Zhao J#, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S*. Rapid generation of a mouse model for Middle East Respiratory Syndrome. Proc Natl Acad Sci U S A. 2014 Apr; 111:4970-4975. (Cited by Nature, Science and Faculty 1000).

6.      Zhao J#, *, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB Jr, Perlman S*. Intranasal treatment with poly I:C protects aged mice from lethal respiratory viral infections. J Virol. 2012 Nov; 86:11416-11424.

7.      Zhao J#, Zhao J, Legge K, Perlman S*. Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest. 2011 Dec; 121:4921-4930. (Commentary by T. Kim and T. Braciale, Cited by Nature/SCIBX and Faculty 1000)

8.      Zhao J#, Zhao J, Perlman S*. T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J Virol. 2010 Sep; 84:9318-9325.

9.      Zhao J#, Zhao J, Van Rooijen N, Perlman S*. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog. 2009 Oct; 5:e1000636. (Cited by Faculty 1000)

10.   Zhao J#, Falcón A#, Zhou H, Netland J, Enjuanes L, Pérez Breña P, Perlman S*. Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication. J Virol. 2009 Mar; 83:2368-2373.

11.   Zhao J#, Wang W#, Wang W, Zhao Z, Zhang Y, Lv P, Ren F, Gao XM*. Comparison of immunoglobulin G responses to the spike and nucleocapsid proteins of severe acute respiratory syndrome (SARS) coronavirus in patients with SARS. Clin Vaccine Immunol. 2007 Jul; 14:839-846.

12.   Zhao J#, Huang Q#, Wang W, Zhang Y, Lv P, Gao XM*. Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus. J Virol. 2007, June; 81:6079-6088.

13.   Zhao J#, Wang W, Yuan Z, Jia R, Zhao Z, Xu X, Lv P, Zhang Y, Jiang C, Gao XM*. A study on antigenicity and receptor-binding ability of fragment 450-650 of the spike protein of SARS coronavirus. Virology. 2007 Mar; 359:362-370.

14.   Zhao JC#, *, Zhao ZD*, Wang W, Gao XM. Prokaryotic expression, refolding, and purification of fragment 450-650 of the spike protein of SARS-coronavirus. Protein Expr Purif. 2005 Feb; 39:169-174.

15.   Zhao J#, Wang W#, Wang GF, Li Y, Zhuang H, Xu X, Ren F, Zhao Z, Gao XM*. Development and evaluation of an enzyme-linked immunosorbent assay for detection of antibodies against the spike protein of SARS-coronavirus. J Clin Virol. 2005 May; 33:12-18.

 

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