王 波
发布时间:2008-12-23  (浏览:)
王波,男,广东省妇幼保健院儿科主任,PICU主任,教授、主任医师。1989年毕业于同济医科大学儿科系;2004年或暨南大学生命科学院医学博士学位。曾在加拿大Mc Master大学、美国南加州大学、澳大利亚悉尼大学Westmead儿童医院、墨尔本大学皇家儿童医院PICU、Murdoch儿科研究所等进行高级研修。从事儿内科临床工作20余年。
临床专长:小儿呼吸疾病、重症监护。
研究方向:HCMV临床病毒的分子遗传学。
教学科研成果:先后获“广州市优秀教师”、“南粤教坛新秀”称号。主持广东省自然基金项目、广东省医学科学技术研究基金项目、广州市属高校科技计划项目等十余项,近10年来致力于HCMV临床病毒的基因结构与功能学研究,部分研究结果被GenBank收录,并在SCI及中华医学会系列期刊等权威期刊上公开发表研究论文33篇。出版《实用临床儿科学》、《小儿内科学(上、下)》等专著4部。
主持项目(部分):
1. Study on the Function of HCMV UL148 Gene in Clinical Isolate. Supported by: Natural Science Foundation of GuangdongProvince.(No.: 9151008901000085)& Health Science Foundation of Guangdong Province. (No.: A2009078)
2. Research of Mechanism of HCMV UL144 Gene in Low-passage Clinical Isolate by EGS Technique. Supported by: NaturalScience Foundation of Guangdong Province. (No.: 06022095) & Health Science Foundation of Guangdong Province.(No.: A2006280)
3. Based on mRNA: EGS Technology, Targeting Inhibit HCMV Clinical Strains UL148 Gene. Supported by:Health Science Foundation of Guangdong Province. (No.: A 2009078)
4. Clinical and Experimental Study on UL97 Gene Mutations and Drug Resistance in Cytomegalovirus Clinical Isolates from Children Leukemia.
Supported by:Health Science Foundation of Guangdong Province. (No.: A2004272)
& Science Foundation of Guangzhou Medical College. (No.: 03-K-15)
论文:
1.      Bo Wang, Jing-Jing Hu, Cui-Fang Yan, et al. Human Cytomegalovirus UL145 and UL136 Genes in Clinical Isolates from Infants. European Journal of Clinical Investigation. 2009(accepted) [SCI Impact factor = 2.961]
2.      Wang B, Yang LP, Bartlam M, et al. New Insights into the Structural Characteristics and Functional Relevance of the Human Cytochrome P450 2D6 Enzyme. Drug Metab Rev. 2009, 41(4):573-643. [SCI Impact factor = 5.622]
3.       Wang B, Zhou SF. Synthetic and Natural Compounds that Interact with Human Cytochrome P450 1A2 and Implications in Drug Development. Curr Med Chem. 2009; 16(31):4066-4218. [SCI Impact factor=4.823]
4.      Wang B, Wang J, Su HH, et al. Genetic Polymorphism of the Human Cytochrome P450 2C9 Gene and its Clinical Significance. Curr Drug Metab. 2009 Sep;10(7):781-834. [SCI Impact factor = 4.326]
5.      Zhou SF, Wang B, Yang LP, et al. Structure, Function, Regulation and Polymorphism and the Clinical Significance of Human Cytochrome P450 1A2. Drug Metab Rev 2009(accepted) [SCI Impact factor = 5.622]
6.      Wang B, Li YQ, Hu JJ, et al. Nucleotide Sequence Characterization and Biological Significance of HCMV UL136 in Low-passage Clinical Isolates in Guangzhou. Chinese Journal of Biomedical Engineering.2009,15(4):244-249.[Chinese]
7.      Wang B, Li YQ, Hu JJ, et al. Identification and Expression of Human Cytomegalovirus UL148 mRNA of Low-passage Clinical Isolates in Guangzhou. Med J China. 2008, 06,88(24):1693-1696.[Chinese]
8.      Wang B, Li YQ, Su HH, et al. Human Cytomegalovirus UL144 Open Reading Frame: Sequence Variability in Guangzhou Congenital Infected Children, Chin J Neuromed 2008, 7(5):511-516. [Chinese]
9.      Wang B, Su HH, H JJ, et al. Characterization of Human Cytomegalovirus (HCMV) UL137 Gene in Low-passage Clinical Isolates in Guangzhou, J Sun Yat-Sen University (Medical Sciences). 2008, 29(3):264-269. [Chinese]
10.  Wang B, Li YQ, Su HH, et al. Human Cytomegalovirus UL143 Gene Polymorphisms in Low-passage Clinical Isolates in Guangzhou, J Trop Med, 2008, 8(4):327-331. [Chinese]
11.  Wang B, Su HH, Chen FM, et al. Investigation and Drug Resistance Analysis of Pathogenic Bacteria of Children Hospital Acquired Pneumonia. Guangdong Medicine. 2008.29(5):781-782. [Chinese]
12.  Wang B, Su HH, Chen FM, et al. Therapeutic Effect of Children Acute Glomerulonephritis Using SHYKFP. Guangdong Medicine. 2008.29(6):1048-1049. [Chinese]
13.  Wang B, Su HH, Wang J, et al. Prognostic and Blood Serum Troponin I of Viral Myocarditis by Injecting 1,6-FDP and SM Injection. The Journal of Practical Medicine. 2008.24(7):1223-1224. [Chinese]
14.  Guo SH, Wang B, et al. Clinical Evaluation of Montelukast Treatment in Infected Infants Wheezing, Chinese General Medical Journal. 2008.11 (11) :993-994. [Chinese]
15.  Guo SH, Wang B, et al. Research of the Role of Diagnosis of Real-time PCR in Children’s Mycoplasma Pneumoniae. Chinese Journal of Practical Pediatrics 2009.6(24):26~28. [Chinese]
16.  Guo SH, Wang B, et al. Comparative Study on PA Test and Real-time PCR Methods in Mycoplasma Pneumoniae Infection. J Sun Yat-Sen University (Medical Sciences). 2008.6(29):83~85. [Chinese]
17.  Zhang HM, Peng SM, & Wang B. Medical Disputes Cause Analysis and Prevention in Pediatrics Department. Modern Hospital Journal. 2008.8 (5) :111-112. [Chinese]
18.  Li LY, Wang B, et al. Nursing Observation of Infants and Young Children with Melamine Urinary Calculi by Combining Chinese and Western Medicine Methods.Southern Journal of Nursing. [Chinese]
19.  Zeng K, Wang B, et al. Correlation Analysis of Common Causes in Children’s Recurrent Respiratory Tract Infection. Journal of Clinical and Experimental Medicine. 2009.8(6):64-66. [Chinese]
20.  Wang B, Li YQ, Zhou TH, et al. Cloning and Analysis of Clinical Low Passage Strain UL97 Gene. Journal of Jinan University(Nature Science Edition), 2005,26(5):694-699. [Chinese]
21.  Wang B, Li YQ, Zhou TH, et al. Simple Amplification of Long Fragment From GC-rich Repetitive Sequences with PCR. Journal of Hunan Agriculture University, 2005.31(6):602-604. [Chinese]
22.  He HK, Li YQ, & Wang B, et al. In vitro Studies of Targeted Cleavage of Human Cytomegalovirus( HCMV) mRNA by RNase P. Chinese Journal of Birth Health & Heredity, 2004,12(2):8-10. [Chinese]
23.  Zhou LP, Li HJ, & Wang B, et al. Targeted in vitro Cleavage of Human Cytomegalovirus UL54 mRNA Segments by RNase P. Chinese Journal of virology,2004,19(2):110-113. [Chinese]
24.  Tian CJ, Li YQ, & Wang B, et al. Cloning and Sequence Analysis of HCMV UL54 Gene of the Clinical Isolate From the Receptor after Allo HSCT. J Clin Int Med, 2005, 4:353-355. [Chinese]
25.  Zhu JM, Wang B, Li YQ, et al. DNA Sequencing Using 230 kb DNA of Virus as Template, Journal of Jinan University (Medicine Edition) ,2004,25(2):154-158. [Chinese]
26.  Wang B, Zhou TH, et al. In vivo Effective Study of Open Reading Frame M43 of Mutant from Mouse Cytomegalovirus, Chinese Journal of Birth Health & Heredity, 2002, 10(4):9-11. [Chinese]
27.  Wang B, Lai YH, Wu ZL, et al. The Effect of Intermittent Deferoxamine Therapy on Relieving Iron Overload in Children with β-thalassemia.  J Appl Clin Pediatr , January 2004, 19(1):33-35. [Chinese]
28.  Wang B, Wu ZL, et al. Effect of Platelet Transfusion and the PAIgG Level Post Chemical Treatment in Children with Acute Leukemia. J Chin Med Pract, 2004, 3(5):385-387. [Chinese]
29.  Wang B, Wu ZL, et al. Combined Therapy with Granulocyte Transfusions and Recombinant Human Granulocyte Colony-stimulating Factor(rhG-CSF) for Severe Agranulocytosis in Refractory Acute Leukemia of Children, J Chin Appl Med, 2004, 4(10):883-885. [Chinese]
30.   Zhan JY, Wang B, et al. Clinical Study on High - dose Methotrexate for Treating Acute Lymphocytic Leukemia in Children. J Appl Clin Pediatr, 2005, 20(7):652-654. [Chinese]
 
 

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