张建业
发布时间:2014-03-28  (浏览:)
    张建业,男,1978年出生,副教授,硕士研究生导师,广东省千百十第七批校级培养对象,中国抗癌协会抗癌药物专业委员会委员,中国药理学会肿瘤药理专业委员会委员。从事中药、天然药物的抗肿瘤研究,把化学成分研究与活性研究相结合。以肿瘤的靶点(包括耐药蛋白、干细胞干性分子、生长通路蛋白等)为研究对象,研究开发新型的抗肿瘤药物。
主持过多项省市级项目,已发表多篇SCI文章,授权专利一项(一种POOL FQ-PCR联合检测肿瘤耐药基因的方法及其试剂盒,公开号102121048A),申请专利一项(专利申请号:201310345808.9)。
2013年9月应邀在美国NIH举办的“10th Annual North American ABC Meeting”上报告了中药千金子的活性成分对MDR细胞K562/ADR的逆转作用。
受教育经历
     2005/09 ? 2008/06,中山大学,肿瘤防治中心,博士
     2000/09 ? 2003/06,北京大学,药学院,硕士
     1996/09 ? 2000/06,北京大学,药学院,学士
研究工作经历
     2008/07 ? 至今,广州医科大学,药学院,副教授
     2012/02 ? 2014/01,香港浸会大学,中医药学院,访问学者
      2003/08 ? 2005/06,北京银建药业有限公司,新药研发项目经理
发表文章
1. Zhang JY, Lin MT, Yi T, Tang YN, Fan LL, He XC, Zhao ZZ, Chen HB. Apoptosis sensitization by Euphorbia factor L1 in ABCB1-mediated multidrug resistant K562/ADR cells. Molecules. 2013, 18(10): 12793-808. (第一作者)
2. Zhang JY, Yi T, Liu J, Zhao ZZ, Chen HB. Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells. J Agric Food Chem. 2013, 61(9): 2188-95. (第一作者)
3. Zhang JY, Liang YJ, Chen HB, Zheng LS, Mi YJ, Wang F, Zhao XQ, Wang XK, Zhang H, Fu LW. Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway. Molecules. 2011, 16(4): 3222-31. (第一作者,并列通讯作者)
4. Zhang JY, Mi YJ, Chen SP, Wang F, Liang YJ, Zheng LS, Shi CJ, Tao LY, Chen LM, Chen HB, Fu LW. Euphorbia factor L1 reverses ABCB1-mediated multidrug resistance involving interaction with ABCB1 independent of ABCB1 downregualtion. J Cell Biochem. 2011, 112(4): 1076-83. (第一作者)
5. Zhang JY, Tao LY, Liang YJ, Chen LM, Mi YJ, Zheng LS, Wang F, She ZG, Lin YC, To KK, Fu LW. Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Mar Drugs. 2010, 8(4): 1469-81. (第一作者)
6. Zhang JY, Tao LY, Liang YJ, Yan YY, Dai CL, Xia XK, She ZG, Lin YC, Fu LW. Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3beta/beta-catenin/c-Myc pathway. Cell Cycle. 2009, 8(15): 2444-50. (第一作者)
7. Zhang JY, Fu LW. Advance of several types of important marine antitumor drugs. Yao Xue Xue Bao. 2008, 43(5): 435-42. (第一作者,Review)
8. Zhang JY, Wu HY, Xia XK, Liang YJ, Yan YY, She ZG, Lin YC, Fu LW. Anthracenedione derivative 1403P-3 induces apoptosis in KB and KBv200 cells via reactive oxygen species-independent mitochondrial pathway and death receptor pathway. Cancer Biol Ther. 2007, 6(9): 1413-21. (第一作者)
9. Tao LY, Li JY, Zhang JY. Brazilein, a compound isolated from Caesalpinia sappan Linn., induced growth inhibition in breast cancer cells via involvement of GSK-3β/β-Catenin/cyclin D1 pathway. Chem Biol Interact. 2013, 206(1): 1-5.
10. Yi T, Tang YN, Zhang JY, Zhao ZZ, Yang ZJ, Chen HB. Characterization and determination of six flavonoids in the ethnomedicine "Dragon's Blood" by UPLC-PAD-MS. Chem Cent J. 2012, 6(1):116.
11. Xia X, Zhang J, Zhang Y, Wei F, Liu X, Jia A, Liu C, Li W, She Z, Lin Y. Pimarane diterpenes from the fungus Epicoccum sp. HS-1 associated with Apostichopus japonicus. Bioorg Med Chem Lett. 2012, 22(8): 3017-9.
12. Yan YY, Zheng LS, Zhang X, Chen LK, Singh S, Wang F, Zhang JY, Liang YJ, Dai CL, Gu LQ, Zeng MS, Talele TT, Chen ZS, Fu LW. Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu. Mol Pharm. 2011, 8(5): 1687-97.
13. Tao LY, L JY and Zhang JY. Brazilein overcame ABCB1-mediated multidrug resistance in human leukaemia K562/AO2 cells. Afr J Pharm Pharmaco. 2011, 5(16): 1937-1944.
14. Wang XH, Wang XK, Liang YJ, Shi Z, Zhang JY, Chen LM, Fu LW. A cell-based screen for anticancer activity of 13 pyrazolone derivatives. Chin J Cancer. 2010, 29(12): 980-7.
15. Tao LY, Zhang JY, Liang YJ, Chen LM, Zhen LS, Wang F, Mi YJ, She ZG, To KK, Lin YC, Fu LW. Anticancer effect and structure-activity analysis of marine products isolated from metabolites of mangrove fungi in the South China Sea. Mar Drugs. 2010, 8(4): 1094-105.
16. Liang YJ, Zhang X, Dai CL, Zhang JY, Yan YY, Zeng MS, Chen LM, Fu LW. Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway. J Biomed Biotechnol. 2009; 2009: 867123.
17. Deng WJ, Zeng ZL, Liang YJ, Dai CL, Zhang JY, Fu LW. Detecting doxorubicin concentration in KBv200 and KB cell xenografts in nude mice by high-performance liquid chromatography. Ai Zheng. 2008, 27(4): 364-8.
 

 

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